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Stoke Therapeutics Names Ian F. Smith CEO

Author: Benzinga Newsdesk | October 06, 2025 06:36am

Leader with Long Track Record in Building World-Class Biopharma Companies and Driving Late-Stage Development and Commercial Execution

Arthur Tzianabos Resumes Chairman of the Board Role

BEDFORD, Mass.--(BUSINESS WIRE)-- Stoke Therapeutics, Inc. (Nasdaq: STOK), a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine, today announced that its Board of Directors has appointed Ian F. Smith as Chief Executive Officer (CEO). Mr. Smith has served as Interim CEO since March 2025 and as a member of Stoke's Board of Directors and advisor to the Company since 2023. He will continue to serve as a Director on the Company's Board of Directors. Arthur Tzianabos, Ph.D., has been a member of the Board of Directors since 2018. He will resume his role as Chairman of the Board after serving as Executive Chairman while the CEO search was conducted.

A global Phase 3 study of the Company's lead investigational medicine, zorevunersen, is underway. Zorevunersen is a first-in-class potential disease-modifying medicine for Dravet syndrome. Dravet syndrome is a severe developmental and epileptic encephalopathy (DEE) characterized by severe, recurrent seizures as well as significant cognitive and behavioral impairments. In February 2025, Stoke entered a collaboration with Biogen Inc. to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights.

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