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Karyopharm Therapeutics Inc. (NASDAQ:KPTI) on Wednesday announced comprehensive financing and capital structure transactions expected to provide the company with $100 million of financial flexibility and additional capital, extending the cash runway into the second quarter of 2026.
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Karyopharm said it continues exploring potential financing and strategic alternatives to enhance liquidity and maximize value. Centerview Partners is the financial advisor.
In addition, the company announced a private placement of approximately $8.75 million.
Karyopharm will sell 1.49 million shares and accompanying warrants to purchase 1.32 million shares with an exercise price of $6.64 per share.
The company expects total revenue, including license and royalty revenue from partners, to be $42 to $44 million and U.S. XPOVIO net product revenue to be approximately $32 million for the third quarter of 2025.
Enrollment continues in the Phase 3 XPORT-EC-042 trial evaluating selinexor as a maintenance-only therapy following systemic therapy versus placebo in patients with TP53 wild-type advanced or recurrent endometrial cancer. The company expects to report topline data from this event-driven trial in mid-2026.
In September, Karyopharm Therapeutics completed enrollment in the Phase 3 SENTRY trial, which is evaluating selinexor in combination with ruxolitinib in JAKi-naïve myelofibrosis patients.
Topline data is anticipated in March 2026.
KPTI Price Action: Karyopharm stock is down 12.74% at $5.03 at publication on Wednesday.
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