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—Data on Structural Lung Changes from a High-Resolution CT Substudy to be Presented as Late-Breaker—
—Additional Analyses Will Highlight Efficacy, Symptom Reduction, and Biomarker Suppression in Patients with Non-Cystic Fibrosis Bronchiectasis—
BRIDGEWATER, N.J., Oct. 16, 2025 /PRNewswire/ -- Insmed Incorporated (NASDAQ:INSM), a people-first global biopharmaceutical company striving to deliver first- and best-in-class therapies to transform the lives of patients facing serious diseases, today announced that it will present six abstracts from the Phase 3 ASPEN study of BRINSUPRI™ (brensocatib) at CHEST 2025, the American College of Chest Physicians Annual Meeting, taking place October 19 - October 22, 2025, in Chicago, IL.
Presentations will feature new prespecified and post-hoc subgroup analyses from the Phase 3 ASPEN trial evaluating brensocatib in patients with non-cystic fibrosis bronchiectasis (NCFB). Highlights include data showing suppression of neutrophil serine proteases (NSPs), as well as late-breaking results demonstrating effects on structural lung changes from a high-resolution CT substudy. Additional presentations feature new insights into treatment outcomes among patients with comorbid chronic obstructive pulmonary disease (COPD), clinical findings in Asian populations, and detailed assessments of symptom burden using the Bronchiectasis Exacerbation and Symptom Tool (BEST), both during and outside of pulmonary exacerbation events. Together, these analyses further explore BRINSUPRI's mechanism of action and its potential impact on disease management.
Posted In: INSM
