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Reported Saturday, Roche Reports evERA Results: All-Oral Giredestrant And Everolimus Show Clinically Meaningful Progression-Free Survival Benefit

Author: Benzinga Newsdesk | October 20, 2025 01:40am
  • Giredestrant plus everolimus reduced the risk of disease progression or death by 44% and 62% in ITT and ESR1-mutated populations, respectively, in a post-CDK inhibitor setting, compared with standard-of-care endocrine therapy plus everolimus1
  • The giredestrant combination was well tolerated; no new safety signals were observed including no photopsia1
  • Overall survival data were immature, but a clear positive trend was seen in both the ITT and ESR1-mutated populations1
  • If approved, giredestrant plus everolimus could be the first and only oral selective oestrogen receptor degrader combination in the post-CDK inhibitor setting

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