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Reported Saturday, Incyte Reports Significant Patient-Reported Benefit In TRuE-AD4 With Improved POEM And DLQI Scores And Reduced Worst Daily Itch From Day 2

Author: Benzinga Newsdesk | October 27, 2025 01:45am

Eight-week results from the TRuE-AD4 trial demonstrate treatment with Opzelura® (ruxolitinib cream) significantly improved the clinical signs of atopic dermatitis (AD), including improved itch as early as Day 2, and was well tolerated in adults with moderate AD who had an inadequate response, intolerance or contraindication to topical corticosteroids (TCSs) and topical calcineurin inhibitors (TCIs)
At Week 8, 70% of patients treated with Opzelura achieved a ≥75% improvement in the Eczema Area and Severity Index (EASI75) and 61.3% achieved Investigator's Global Assessment Treatment Success (IGA-TS), co-primary endpoints of the study
Based on these results, Incyte expects to file a Type-II variation application for ruxolitinib cream 1.5% for the treatment of adults with moderate AD in the European Union (EU) by end of year

Posted In: INCY