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- ATNM-400 exhibits superior efficacy with 3-5x greater tumor growth inhibition compared to front line therapy osimertinib (EGFR TKI TAGRISSO®), second line therapy Dato-DXd (Trop-2 ADC DATROWAY®) and third line therapy amivantamab (EGFR-cMET bispecific RYBREVANT®)
- Combination of ATNM-400 and osimertinib resulted in complete tumor regression in 100% of tumor bearing animals; synergistic mechanism supported by increased ATNM-400 target antigen expression after EGFR inhibition with osimertinib
- Improved progression free survival has been demonstrated clinically with the combination of osimertinib and external beam radiotherapy providing strong rationale for a combination with targeted alpha-therapy
- Data validates the multi-tumor potential of ATNM-400 in multiple disease and treatment settings that support several blockbuster drugs
NEW YORK, Oct. 27, 2025 /PRNewswire/ -- Actinium Pharmaceuticals, Inc. (NYSE:ATNM) (Actinium or the Company), a pioneer in the development of differentiated targeted radiotherapies, today announced the presentation of the first ever preclinical data of ATNM-400 in non-small cell lung cancer (NSCLC). ATNM-400 a novel, multi-indication first-in-class antibody radioconjugate armed with the potent alpha-emitter Actinium-225 (Ac-225) is Actinium's lead solid tumor program, which is also being studied in prostate cancer. The data presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics studied ATNM-400 in Epithelial Growth Factor Receptor (EGFR)-mutant NSCLC models.
ATNM-400 demonstrated superior efficacy with 3-5x greater tumor growth inhibition compared to standard-of-care therapies across EGFR-mutant NSCLC including:
Frontline: Osimertinib (TARGRISSO®, AstraZeneca) an EGFR tyrosine kinase inhibitor (TKI)
Second line: Dato-DXd (DATROWAY®, AstraZeneca/Daiichi Sankyo) a Trop-2 antibody drug conjugate (ADC)
Third line: Amivantamab (RYBREVANT®, J&J), an EGFR-cMET bispecific antibody
ATNM-400 also demonstrated synergistic activity in combination with osimertinib with complete tumor regression in 100% of tumor-bearing animals. The synergistic mechanism of this combination is supported by increased expression of the ATNM-400 target antigen after EGFR inhibition with osimertinib. In addition, previously published data of external beam radiotherapy (EBRT) combined with osimertinib resulted in improved progression free survival (PFS) compared to osimertinib alone, providing a strong clinical rationale for combining targeted alpha-therapy via ATNM-400 with EGFR targeting therapies Sampath et al. (AstraZeneca & UT Southwestern Harold C. Simmons Comprehensive Cancer Center).
Posted In: ATNM
