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Lisata Therapeutics, Inc. (NASDAQ:LSTA) ("Lisata" or the "Company"), a clinical-stage pharmaceutical company developing innovative therapies for the treatment of advanced solid tumors and other serious diseases, today highlighted positive preclinical data as announced by Lisata's licensing partner, Catalent, Inc. ("Catalent"), at the 16th Annual World ADC San Diego Conference, held November 3-6, 2025. Catalent's presentation included data demonstrating the positive impact of incorporating Lisata's proprietary iRGD cyclic peptide product candidate, certepetide, and its analogs as a payload in Catalent's SMARTag® antibody-drug conjugate ("ADC") technology platform. Specifically, Catalent reported preclinical results showing that using certepetide as a non-cytotoxic ADC payload not only improved ADC efficacy but also broadened the distribution of the cytotoxic payload within the tumor microenvironment. A summary of these results can be found here in the Company's latest corporate presentation.
"This data is encouraging as it reinforces the large and growing body of evidence indicating that certepetide can enhance the targeting, penetration, and effectiveness of therapeutic agents - in this case, ADCs - in which it is chemically incorporated or co-administered," stated Kristen K. Buck, M.D., Executive Vice President of Research and Development and Chief Medical Officer of Lisata. "ADCs are one of the fastest growing and most exciting therapeutic categories in drug development. These results underscore our belief in the value of our licensing partnership with Catalent and supports our strategy of leveraging certepetide's unique mechanism to enhance the therapeutic potential across all modalities of treatments."
Lisata licensed certepetide and its analogs to Catalent for use with its SMARTag® technology platform, as part of its Enhanced Conjugates innovations. Enhanced Conjugates are designed to amplify the effect of a cytotoxic payload by combining it with a non-cytotoxic payload, such as certepetide, with the goal of amplifying efficacy without compromising safety.
Posted In: LSTA
