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— Phase 2 SPRING Trial Open Label Extension Showed Favorable Safety and Consistent Improvements in Key Biomarkers in PSC Patients Treated with Nebokitug for Up to 48 Weeks—
—New Clinical Data Provides Insights on Nebokitug's Direct Macrophage-Mediated Mechanisms that Are Key to PSC Disease Progression—
—All Three Presentations Have Been Designated as Posters of Distinction—
TEL AVIV, Israel and WASHINGTON, Nov. 06, 2025 (GLOBE NEWSWIRE) -- Chemomab Therapeutics Ltd. (NASDAQ:CMMB) (Chemomab), a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need, today announced that abstracts that highlight new clinical data from the nebokitug Phase 2 SPRING trial in primary sclerosing cholangitis (PSC) will be presented on November 10, 2025, at the American Association for the Study of Liver Disease (AASLD) The Liver Meeting® 2025. Data presented from the SPRING trial open label extension (OLE) demonstrate continued and consistent effects of nebokitug on key inflammatory and fibrotic biomarkers, further reinforcing its disease-modifying potential in PSC. Two posters will present new clinical data that provides additional insights into the macrophage-related mechanism of action of nebokitug, a first-in-class antibody that inhibits the soluble protein CCL24, a key driver of disease processes in fibro-inflammatory diseases such as PSC. These results show that nebokitug may halt or slow disease progression and improve clinical outcomes — the primary objectives of the upcoming Phase 3 study.
Posted In: CMMB
