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Can-Fite BioPharma Ltd. (NYSE:CANF) (TASE: CANF), a biotechnology company advancing a pipeline of proprietary small molecule drugs targeting oncological and inflammatory diseases, announced today it received a Notice of Allowance from the National Institute of Industrial Property of Brazil for its patent application titled "An A3 Adenosine Receptor Ligands For Use in Treatment of a Sexual Dysfunction". The invention addresses the use of Can-Fite's CF602 drug candidate as an oral or topical treatment for erectile dysfunction (ED) patients living with diabetes and those who are non-responders to ED drugs currently on the market.
"This latest patent in Brazil geographically expands intellectual property protection for CF602 in ED beyond the major markets of the U.S. and Europe where patents have already been granted," stated Motti Farbstein, Can-Fite CEO. "Given the large percentage of non-responders and those living with diabetes who are contraindicated for taking the most widely prescribed ED medications, we believe CF602 has the potential to meet a large and unmet need."
Standard of care ED drugs including Viagra, Cialis, Levitra, and Stendra are oral phosphodiesterase type 5 (PDE5) inhibitors that work for approximately 65%-70% of patients in today's $3.2 billion ED market. Yet, an estimated 30% to 35% of ED patients are non-responders, and these drugs can be contraindicated for people living with diabetes representing 16 million men in the U.S.
A study published in the journal Andrologia by Can-Fite scientists suggests that CF602 could potentially offer an alternative to the current drugs on market. A full erectile recovery was achieved following a single dose of CF602 with restored muscle collagen ratio and endothelial cell function. Can-Fite's CF602, an allosteric modulator of the A3 adenosine receptor (A3AR), applied topically or orally in a diabetic rat model, resulted in increased arterial blood flow and significant dose-dependent improvements in intracavernosal pressure (ICM), smooth muscle/collagen ratio, vascular endothelial growth factor and endothelial nitric oxide synthase.canf
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